Endoscopy Innovation and Research

Adoption of Cytosponge technology for evaluation in dyspepsia pathways and Barrett’s surveillance

Assessment of aerosol/droplet generation during luminal endoscopy in COVID 19 era

Evolution of “under-water” luminal endoscopy techniques

Participation in the ESD registry

AI prediction of abnormalities in ulcerative colitis & Barrett’s surveillance endoscopy

Registry of Purastat following endoscopic resection

“Sip till Send” with pre-OGD simethicone/NAC drink for improved patient tolerance and endoscopic visualisation

Site for EUROPAC pancreatic cancer surveillance in high-risk family cohorts

Evaluation of single use ERCP EXALT duodenoscope – multicentre UK study lead by NUH (“SURE study”)

Evaluation of single use ERCP AMBU duodenoscope – multicentre UK study lead by NUH (“ASSURE study”)

Safety and Efficacy of Moray forceps biopsy for pancreatic cysts sampling (Vasan/Guru/Martin)

European Cholangioscopy Evaluation of Spyglass in the visual evaluation and tissue biopsy for indeterminate biliary strictures

Remote pre-assessment and individualised risk assessment prior to ERCP endoscopy

PPP and VMI cost reduction for restocking/reordering endoscopic consumables

UK multicentre safety and efficacy trial of EUS biliary drainage using electrocautery-enhanced LAMS stents

Virtual electronic pre-ERCP consent pilot with EIDO

Preceptorship/Proctorship training of established consultants in EUS/ERCP

Introduction of “endohepatology” service using EUS to assess liver elastography/ liver biopsy and EUS portal pressure measurement (EUS PPG)

1. Project DELTA - Integrated diagnostic solution for early detection of oesophageal cancer 21GA018 / IRAS 283505. Cytosponge in Barrett's surveillance.
2. PROBAN BEST2 10GA026 / IRAS 57563. Use of Cytosponge in post RFA/EMR follow up.
3. CAD - Computer aided detection and characterization of Barrett neoplasia 20EY001 / IRAS 281945.
4. NEED - Non-Invasive Testing for Early Oesophageal Cancer and Dysplasia 19GA067 / IRAS 239428.
5. EndoRotor - Prospective Randomized Controlled Trial Comparing the Safety and Performance of the Interscope EndoRotor® Mucosal Resection System with Continued Ablative Therapy in Subjects with Refractory Dysplastic Barrett's Esophagus. 20GA049 / IRAS 243999. 
6. PREFER - Endoscopic management of patients with high risk T1a and T1bN0M0 esophageal adenocarcinoma: a prospective multicentre registry. 21EY001 / IRAS 236609.
7. ROSPERO. PROspective multicentre Study to identify diagnostic key PERfOrmance indicators in Upper GI Endoscopy. 21EY002/IRAS 281099
8. SUBLYME-2. External validation of an individual risk calculator to predict lymph node metastases in patients with submucosal (T1b) esophageal adenocarcinoma.
9. OSCAR. Oesophageal Squamous cell CARcinoma (OSCAR) Study: Study to determine novel biomarkers for early diagnosis and to inform therapeutic management of Oesophageal Squamous Cell Dysplasia and Carcinoma REC 15/EE/0226.
10. WATS-EURO 2. A multicentre prospective cohort study comparing random biopsies with Wide-Area Transepithelial brush-Sampling (WATS) for surveillance of Barrett’s Esophagus.
11. Augmented response of volatile biomarkers in the assessment of oesophagogastric cancer (AROMA 1 and BIORESOURCE). IRAS ID: 30348
12. An investigation on Cytosponge and molecular biomarkers to identify patients with gastric intestinal metaplasia (GIM): CyGIM study

1. Barrett's Esophagus Screening Study (BEST)
2. Evaluation of a Non-Endoscopic Immunocytological Device (Cytosponge) for Barrett’s Esophagus Screening in a Case-Control Study (BEST2)
3. Barrett's Esophagus Screening Study 3 (BEST3)
4. Barrett's Randomised Intervention for Dysplasia by Endoscopy (BRIDE)
5. Barrett's oesophagus and optical biopsy using elastic scattering spectroscopy to target high risk lesions (BOOST)
6. Captivator EMR Registry
7. UK Radiofrequency Ablation (RFA) Registry
8. Wide Tissue Acquisition Technique for Barrett’s (WATS)
9. Combination of Autofluorescence imaging and Confocal laser Endomicroscopy to diagnose dysplasia in Barrett’s oesophagus (ACE-B Study) 

Pilot use of HEE “Hololens” mixed reality headsets for remote supervision.