Genomic and Molecular Medicine Service, Nottingham

The Genomic and Molecular Medicine Service forms part of the integrated ‘East Midlands and East of England Genomics Laboratory’ (EMEE) service.

The EMEE is responsible for delivery of the genomic tests defined in the new National Genomic Test Directories.  The tests will be either delivered locally or via the EMEE laboratory hub at Addenbrooke’s Hospital, Cambridge. For current turnaround times please see table below.

For further details of the tests delivered locally, select the links below to go to the pages for the Cytogenetics, Molecular Genetics and Molecular Diagnostics sections of the laboratory. 

East GLH and Nottingham University Hospitals NHS Trust comply with the Data Protection Act and the General Data Protection Regulation (GDPR) and take all possible care to maintain security and confidentiality of personal data.

When required by law or contractual obligation the laboratory will release confidential information. Any request to share patient information is managed and approved in accordance with NUH policies.  

Further information on how patient data is maintained can be found here:

Data Requests & Your Privacy | NUH

Page last updated 13/11/2024. Please note that if printed, this information is only valid on the day of printing.

Current turnaround times

 

September 2024

Rare Disease Cytogenomics

Clinical Urgency

Example Tests

NHSE Target TAT (Days)

Percentage within Standard

Average TAT (Mean days)

Urgent - Rapid

Microarray / karyotypes for prenatal / urgent postnatal (e.g. neonatal referrals)

14

91%

10

Non-urgent - Standard

Standard paediatric or fetal loss microarray

42

69%

35.1

Non-urgent - Standard

Postnatal karyotyping (e.g. fertility or familial microarray follow-up)

42

73%

34.4
         

Rare Disease Molecular

Clinical Urgency

Example Tests

NHSE Target TAT (Days)

Percentage within Standard

Average TAT (Mean, Days)

Urgent – Ultra Rapid

QF-PCR for rapid trisomy detection

3

79%

2.4

Urgent – Ultra Rapid

PCR based tests where the result is needed urgently for prenatal diagnosis

3

50%

4.6

Urgent – Rapid

PCR based tests for predictive testing

14

74%

14.9

Non-Urgent – Standard

Rare disease (Fragile X, PWS,AS)

42

94%

41.1

Non-Urgent – Standard

Rare disease single gene screening, known familial variant testing & standard STR based analysis

42

73%

39.7

Non-Urgent – Standard

Rare disease small panel testing (<10 genes)

42

93%

69.7

Non-Urgent – Complex standard

Large gene panels (>10 genes), WES and WGS

84

37%

202.8
         

Haem-Onc Cytogenomics

Clinical Urgency

Example Tests

NHSE Target TAT (Days)

Percentage within Standard

Average TAT (Mean, Days)

Urgent – Ultra Rapid

Urgent haemato-oncology FISH (e.g. BCR/ABL1, PML/RARA)

3

60%

2.8

Urgent - Rapid

Urgent haemato-oncology karyotyping/array/FISH

14

94%

9

Non-urgent - Standard

Standard haemato-oncology karyotyping/array/FISH

21

84%

18.8
         

Haem-Onc Molecular

Clinical Urgency

Example Tests

NHSE Target TAT (Days)

Percentage within Standard

Average TAT (Mean, days)

Urgent – Ultra Rapid

AML(FLT3, NPM1)

3

47%

3.7

Urgent - Rapid

AML(CBF)

14

100%

7.6

MPN(JAK2, CALR)

14

86%

12.8

Urgent - Rapid

Chimerism

14

96%

12.2

Diagnostic BCR::ABL1

14

86%

10.4

BCR::ABL1 (Monitoring)

14

50%

15

 

 

 

 

 

Solid Cancer  

Clinical Urgency

Example Tests

NHSE Target TAT (Days)

Percentage within Standard

Average TAT (Mean, Days)

Urgent – Rapid

FISH for solid cancers

14

90%

10

Urgent – Rapid

BRAF

14

100%

6

Non-urgent Std

NGS-targeted DNA

21

98%

13.7

Non-urgent Std

NGS-targeted RNA

21

98%

14.1

Non-urgent Std

FISH for solid cancers

21

95%

18.5

Non-urgent Std

MSI testing & MLH1 promoter methylation

42

67%

40.3