Hereditary breast cancer

The resources below have been developed to support implementation of mainstreaming of the R208 Hereditary breast cancer panel which includes BRCA1/2, PALB2, ATM, RAD51C, RAD51D and CHEK2 testing through cancer services in Nottinghamshire, Lincolnshire and Derbyshire. We call this Mainstreaming Cancer Genetics (MCG).

This model of gene testing has been successfully implemented at other cancer genetics services such as the Marsden Hospital. 

The resources listed here have been based around the published material from the Marsden Hospital and adapted for use within our Trust and the district hospital which we serve. Any of the specialist nurses or clinicians involved in the care of women with breast cancer can complete the training resources.

Please note that RAD51C, RAD51D, ATM and CHEK2 genes were only added to the panel in our area from 1/1/2023

If you have queries please contact: nuhnt.clinicalgenetics@nhs.net.

Steps for training

1. Email nuhnt.clinicalgenetics@nhs.net to arrange a time for face-to-face or virtual training.
2. Read the frequently asked questions before the training:   MCG-FAQ1 V4.doc [doc] 123KB

• Frequently asked questions booklet:     MCG-FAQ1 V4.doc [doc] 123KB
• Protocol for the Nottingham Breast Institute:    MCG-P1-V8-Breast-Notts-protocol.pptx [pptx] 101KB
• Family history questionnaire:  Cancer FH form (v3.1 NCGS_2024).pdf [pdf] 188KB
• Blood form- Test request form East_GLH_Rare_Disease_Test_Order_Form
• Record of discussion (consent) form for patients with breast cancer:    MCG-BREAST-ROD-FORM-19.11.docx [docx] 35KB

UK Cancer Genetics Group management guidelines for BRCA and PALB2 can be found via the UKCGG website (www.ukcgg.org) here: UKCGG leaflets and guidelines - Cancer Genetics Group

 

 

• A normal R208 result:   MCG GRL1 R208 normal result updated 2023. doc.doc [doc] 78KB
• A positive R208 result:   MCG GRL2 R208 positive result updated 2023.doc [doc] 81KB
• Unclassified variant:    MCG GRL3 R208 VUS updated 2023.doc [doc] 78KB