Molecular Diagnostic Services
Molecular Tests Performed
|
Clinical Indication |
NGTD code |
Genomic Test |
Target TAT |
|
Myeloproliferative Neoplasms (MPN) |
M85.14 |
JAK2 V617F hotspot |
14 |
|
|
M85.16 |
CALR exon 9 hotspot |
14 |
|
|
M85.11 |
Diagnostic BCR::ABL1 |
14 |
|
Acute Myeloid Leukaemia (AML) |
M80.18/M80.21 |
FLT3 ITD/TKD hotspot |
3 |
|
|
M80.22 |
NPM1 exon 12 hotspot |
3 |
|
|
M80.42 |
RUNX1::RUNX1T1 RT-qPCR |
14 |
|
|
M80.43 |
CBFB::MYH11 RT-qPCR |
14 |
|
|
M80.23 |
IDH1 mutation hotspot |
14 |
|
|
M80.24 |
IDH2 mutation hotspot |
14 |
|
|
M80.10 |
PML::RARA RT-qPCR |
3 |
|
Acute Lymphoblastic Leukaemia (ALL) |
M91.8 |
Diagnostic BCR::ABL1 |
3 |
|
Chronic Myeloid Leukaemia (CML): Diagnostic |
M84.1 |
Diagnostic BCR::ABL1 |
14 |
|
Chronic Myeloid Leukaemia (CML): Monitoring (MRD) |
M84.2 |
MRD BCR::ABL (p210 only) |
14 |
|
Monitoring of haematopoietic stem cell transplant (STR) |
M118.1 |
Chimerism |
14 |
|
Solid Tumour |
M1.1 |
Colorectal Cancer DNA |
21 |
|
|
M1.6 |
Colorectal Cancer RNA |
|
|
|
M4.1/M4.3 |
Non-Small Cell Lung Cancer DNA |
21 |
|
|
M4.2 |
Non-Small Cell Lung Cancer RNA |
|
|
|
M7.1 |
Melanoma DNA |
21 |
|
|
M7.3 |
Melanoma RNA |
|
|
|
M8.1 |
Gastroinstetinal Stromal Tumour DNA |
21 |
|
|
M8.2 |
Gastroinstetinal Stromal Tumour RNA |
|
|
|
M9.1/M10.1+others |
Thyroid Cancer DNA |
21 |
|
|
M9.2/M10.2+others |
Thyroid Cancer RNA |
|
|
|
M220.1 |
Cholangiocarcinoma RNA |
21 |
|
|
M220.6 |
Cholangiocarcinoma DNA |
NGTD-National Genomic Test Directory
Tests specified within the genomics test directory that are not provided by this laboratory, are sent to Cambridge University Hospitals or, in some occasions, referred to specialist genetic laboratories outside of our GLH, please see the table below for details:
Molecular Tests Referred to other Laboratories
|
Referral Clinical Indication |
NGTD code |
Referral laboratory |
|
AML baseline for MRD |
M80.9 M80.10 M80.11 M80.12 M80.13 |
Guy’s Hospital or Bristol Hospital |
|
BCR::ABL1 p190 MRD |
M84.2 |
Hammersmith |
|
BCR::ABL1 p210 transcript identification |
M84.1 |
Addenbrookes, Cambridge |
|
BCR::ABL1 p210 rare transcript identification and MRD |
M84.23 |
Hammersmith |
|
BCR::ABL TKD mutation screen |
M84.8 |
King’s College Hospital |
|
JAK2 exon 12 |
M85.15 |
Addenbrooke’s, Cambridge |
|
MPL exon 10 |
M85.17 |
Addenbrooke’s, Cambridge |
|
cKIT |
M86.1 |
Addenbrooke’s, Cambridge |
|
Lineage specific chimerism |
M118.1 |
Forward EDTA to relevant monitoring laboratory |
|
Myeloid NGS |
M80.2 |
Addenbrooke’s, Cambridge |
Page last updated 19/06/2024. Please note that if printed, information is only valid on the day of printing.